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GNF351

CAT: 0804-HY-102023-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-102023-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GNF351 is a full aryl hydrocarbon receptor (AHR) antagonist. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR with an IC50 of 62 nM. GNF351 is minimal toxicity in mouse or human keratinocytes[1].
CAS Number
1227634-69-6
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Aryl Hydrocarbon Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/gnf351.html
Purity
99.87
Solubility
DMSO : ≥ 125 mg/mL
Smiles
CC1=CN=CC(C2=NC(NCCC3=CNC4=C3C=CC=C4)=C5N=CN(C(C)C)C5=N2)=C1
Molecular Formula
C24H25N7
Molecular Weight
411.50
Precautions
H315, H319, H320
References & Citations
[1]van den Bogaard EH, et al. Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation. J Invest Dermatol. 2015 May;135 (5) :1320-1328.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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