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Maleimide

CAT: 0804-HY-W007324-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W007324-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Maleimide can be used for production of antibody-drug conjugate (ADC) which is used in cancer research. Maleimide also be leveraged for the preparation of fluorogenic probe, which is mainly used for the specific detection of thiol analytes[1][2].
CAS Number
541-59-3
UNSPSC
12352005
Hazard Statement
H300, H314, H317
Target
ADC Linker; Biochemical Assay Reagents
Type
Natural Products
Related Pathways
Antibody-drug Conjugate/ADC Related; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/maleimide.html
Concentration
10mM
Purity
99.98
Solubility
DMSO : ≥ 100 mg/mL|H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(N1)C=CC1=O
Molecular Formula
C4H3NO2
Molecular Weight
97.07
Precautions
H300, H314, H317
References & Citations
[1]Renault K, et, al. Covalent Modification of Biomolecules through Maleimide-Based Labeling Strategies. Bioconjug Chem. 2018 Aug 15;29 (8) :2497-2513.|[2]Zhang S, et, al. A Maleimide-functionalized Tetraphenylethene for Measuring and Imaging Unfolded Proteins in Cells. Chem Asian J. 2019 Mar 15;14 (6) :904-909.|[3]Li T, et al., A novel application of maleimide for advanced drug delivery: in vitro and in vivo evaluation of maleimide-modified pH-sensitive liposomes. Int J Nanomedicine. 2013;8:3855-66.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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