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Isosaponarin

CAT: 0804-HY-N2589-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2589-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Isosaponarin is a flavone glycoside isolated from wasabi leaves. Isosaponarin is a P4HA2 enzymatic agonist. Isosaponarin increases collagen synthesis via up-regulated TGF-β type II receptor (TβR-II) and prolyl 4-hydroxylase (P4H) proteins production, promoting skin health and wound healing. Isosaponarin-rich plants exhibit strong antimicrobial, antioxidant, anti-hyaluronidase, antiplatelet, anti-atopic dermatitis, and anti-tumor effects[1][2][3][4][5].
CAS Number
19416-87-6
UNSPSC
12352005
Target
Collagen; TGF-β Receptor
Type
Natural Products
Related Pathways
Cytoskeleton; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Infection; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/isosaponarin.html
Purity
99.59
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1C=C(C2=CC=C(O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)C=C2)OC4=CC(O)=C([C@H]5[C@@H]([C@H]([C@@H]([C@@H](CO)O5)O)O)O)C(O)=C14
Molecular Formula
C27H30O15
Molecular Weight
594.52
References & Citations
[1]Masashi Nagai, et al. The effect of isosaponarin isolated from wasabi leaf on collagen synthesis in human fibroblasts and its underlying mechanism. J Nat Med. 2010 Jul;64 (3) :305-12.|[2]Lu CW, et al. The Effect of Isosaponarin Derived from Wasabi Leaves on Glutamate Release in Rat Synaptosomes and Its Underlying Mechanism. Int J Mol Sci. 2022 Aug 6;23 (15) :8752.|[3]Kaynat Firdos et al. Harnessing isosaponarin: A multifaceted bioactive and therapeutic potential compound from nature. Biol. Biomed. J. (2025) Vol. 3, Issue (2) Pages 1-12.|[4]Chi Z, et al. P4HA2 promotes proliferation, invasion, and metastasis through regulation of the PI3K/AKT signaling pathway in oral squamous cell carcinoma. Sci Rep. 2024 Jul 1;14 (1) :15023.|[5]Hashimoto, et al. Dietary Isosaponarin is Intestinally Metabolized to Isovitexin, Most of Which are Excreted in Feces without Being Absorbed. Asian Journal of Food Research and Nutrition,2 (3) :104-116.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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