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RP-832c

CAT: 0013-GTR19144755-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19144755-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RP-832c is a synthetic analog of a host defense peptide (HDP) that targets the mannose receptor CD206 on M2-polarized macrophages with a Kd of 3.5 μM. Upon binding to CD206, RP-832c induces significant conformational changes in the receptor, activating signaling pathways that lead to rapid apoptosis of CD206-positive M2 macrophages and their repolarization to the M1 phenotype. Treatment with RP-832c significantly reduces CD206 gene expression in M2 macrophages and temporarily increases the expression of the M1 macrophage marker TNF-α. RP-832c is applicable for research on T-cell lymphomas (CTCL) and idiopathic pulmonary fibrosis (IPF) .
Field of Research
Cell Biology
Molecular Weight
1367.60
Storage Conditions
-20°C
Notes
For research use only.

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