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NAB815

CAT: 0013-GTR19144685-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19144685-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NAB815 is a specific inhibitor of Stx2a (Kd= 0.01 μM) /TLR4 interactions. It inhibits the interaction between neutrophils and Stx2a with an IC50 of 0.057 μg/mL. NAB815 also prevents the formation of extracellular vesicles (EV) containing Stx2 from leukocytes and platelets, reducing its toxicity in cells (Vero cells) and in animal models (CD-1 mice) . Additionally, NAB815 decreases the bacterial load in the kidneys, urine, and bladder of mice infected with Escherichia coli. It is applicable for research in hemolytic uremic syndrome (HUS) .
Field of Research
Immunology & Inflammation, Infectious Disease & Virology
Molecular Weight
1175.42
Storage Conditions
-20°C
Notes
For research use only.

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