PROTAC PARP1 degrader-1

PROTAC PARP1 degrader-1

• UNSPSC Description: PROTAC PARP1 degrader-1 (Compound CN0) is a PROTAC degrader of PARP1. PROTAC PARP1 degrader-1 activates the cGAS/STING immunity pathway and eventually enhances T cell killing of tumor cells. PROTAC PARP1 degrader-1 inhibits DNA damage repair, resulting in highly efficient accumulation of cytosolic DNA fragments (Blue: CRBN ligand, Black: linker; Pink: PARP1 inhibitor)[1].
• Target Antigen: PARP; PROTACs
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics;PROTAC
• Applications: COVID-19-anti-virus
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/protac-parp1-degrader-1.html
• Solubility: 10 mM in DMSO
• Smiles: NC(C1=CC=CC2=CN(N=C21)C3=CC=C(C=C3)C4CN(CCC4)C5=C(C6=CC=C5)C(N(C6=O)C7CCC(NC7=O)=O)=O)=O
• Molecular Weight: 576.60
• References & Citations: [1]Lin S, et al. Discovery of CN0 as a novel proteolysis-targeting chimera (PROTAC) degrader of PARP1 that can activate the cGAS/STING immunity pathway combined with daunorubicin. Bioorg Med Chem. 2022 Sep 15;70:116912.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported