SGC-STK17B-1

SGC-STK17B-1

• CAS Number: 2650530-00-8
• UNSPSC Description: SGC-STK17B-1 is an ATP-competitive and selective STK17B (a member of DAPK family) inhibitor (IC50: 34 nM, KD: 5.6 nM)[1].
• Target Antigen: DAPK; Others
• Type: Reference compound
• Related Pathways: Apoptosis;Others
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/sgc-stk17b-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(CSC1=NC=NC2=C1SC(C3=CC4=C(C=CC=C4)S3)=C2)O
• Molecular Weight: 358.46
• References & Citations: [1]Picado A, et al. A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. J Med Chem. 2020 Dec 10;63(23):14626-14646.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported