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Marcfortine A

CAT: 0804-HY-126638Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-126638Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Marcfortine A is an indole alkaloid originally isolated from P. roqueforti. It has nematocidal activity against the parasitic nematode H. contortus (LD99=0.06 μg/mL) and inhibits motility of adult worms (EC50=2 μM) . Marcfortine A eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s=0.33, 0.11, and 2.5 mg/animal, respectively) . It dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α3 subunit-containing human nicotinic acetylcholine receptors (nAChRs) and muscle-type nAChRs, respectively.
CAS Number
75731-43-0
Product Name Alternative
NSC 324645
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/marcfortine-a.html
Smiles
CN1[C@]23[C@](C[C@]4(N(CCCC4)C3)C1=O)([H])C(C)([C@@]5(C6=CC=C(OC(C)(C)C=CO7)C7=C6NC5=O)C2)C
Molecular Formula
C28H35N3O4
Molecular Weight
477.60
References & Citations
[1]Polonsky, et al. Isolation and structure (X-ray analysis) of marcfortine A, a new alkaloid from Penicillium roqueforti. J.C.S. Chem. Comm. 0 (13), 601-602 (1980) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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