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Clofarabine

CAT: 0804-HY-A0005-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-A0005-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Clofarabine, a nucleoside analogue for research of cancer, is a potent inhibitor of ribonucleotide reductase (IC50=65 nM) by binding to the allosteric site on the regulatory subunit[1].
CAS Number
123318-82-1
UNSPSC
12352005
Hazard Statement
H300
Target
Apoptosis; Autophagy; Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Metabolic Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/clofarabine.html
Purity
99.88
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O[C@H]1[C@H](F)[C@H](N(C=N2)C3=C2C(N)=NC(Cl)=N3)O[C@@H]1CO
Molecular Formula
C10H11ClFN5O3
Molecular Weight
303.68
Precautions
H300
References & Citations
[1]Peter L Bonate, et al. Discovery and development of clofarabine: a nucleoside analogue for treating cancer. Nat Rev Drug Discov. 2006 Oct;5 (10) :855-63.|[2]Hai-Bo Liu, et al. [Effect of clofarabine on proliferation and Bcl-2 expression of NB4 cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Jun;20 (3) :571-3.|[3]Jia-Jie Luan, et al. Dosing-time contributes to chronotoxicity of clofarabine in mice via means other than pharmacokinetics. Kaohsiung J Med Sci. 2016 May;32 (5) :227-34.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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