Products for Research Use Only

Recombinant Human HER2 Protein

CAT: 0013-GTR19125468-01Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR19125468-01Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recombinant Human Receptor Tyrosine-protein Kinase ErbB-2 is produced by our Mammalian expression system and the target gene encoding Thr23-Thr652 is expressed with a human IgG1 Fc tag at the C-terminus.
Product Name Alternative
Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; Proto-oncogene Neu; Tyrosine kinase-type cell surface receptor HER2; ERBB2; MLN19; NGL; TKR1
UniProt
P04626
Expression Region
Thr23-Thr652
Conjugation
Unconjugated
Tag
C-Fc
Origin
Human
Field of Research
Signal Transduction
Endotoxin
< 1 EU/μg as determined by LAL test.
Purity
SDS-PAGE: Greater than 95% as determined by reducing SDS-PAGE.. SEC-HPLC: Greater than 95% as determined by SEC-HPLC. (QC verified)
Bioactivity
ELISA: Immobilized Anti-Human EGFR Antibody (AMI_bio, Research Grade) (Cat#orb2992597) at 1μg/ml (100 μl/well) can bind Recombinant Human EGFR (C-Fc) (Cat#orb2994534) *. *: Biotinylated by NHS-biotin prior to testing.The ED50 of Recombinant Human EGFR (C-Fc) (Cat#orb2994534) is 22.33ng/ml. (Regularly tested) .
Form
Lyophilized
Molecular Weight
Predicted: 96.5 KDa. Observed: 120-145 KDa, reducing conditions
Storage Conditions
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Notes
For research use only.
Preservative
0.2 μm filtered solution of PBS, pH 7.4.

UniProtKB · P04626

Receptor tyrosine-protein kinase erbB-2

ERBB2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P04626
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ERBB2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
B2RZG3, B4DHN3, Q14256, Q6LDV1, Q9UMK4, X5D2V5
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorKinaseReceptorTransferaseTyrosine-protein kinase

Coding sequence diversity

Alternative initiationAlternative splicingChromosomal rearrangement

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneCell projectionCytoplasmEndosomeMembraneNucleus

Disease

Disease variant

PTM

Disulfide bondGlycoproteinPhosphoprotein

Domain

SignalTransmembraneTransmembrane helix

Biological process

TranscriptionTranscription regulation