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Recombinant Human PCSK9 Protein

CAT: 0013-GTR19123801-01Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR19123801-01Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recombinant Human Proprotein convertase subtilisin/kexin type 9 is produced by our Mammalian expression system and the target gene encoding Gln31-Gln692 (Asp374Tyr) is expressed with a 6His tag at C-terminus.
Product Name Alternative
Proprotein Convertase Subtilisin/Kexin Type 9; Neural Apoptosis-Regulated Convertase 1; NARC-1; Proprotein Convertase 9; PC9; Subtilisin/Kexin-Like Protease PC9; PCSK9; NARC1
UniProt
Q8NBP7
Expression Region
Gln31-Gln692 (Asp374Tyr)
Tag
C-6His
Origin
Human
Field of Research
Metabolism Research
Endotoxin
< 1 EU/μg as determined by LAL test.
Purity
SDS-PAGE: Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Bioactivity
ELISA: Immobilized Anti-Human PCSK9 mAb (Human IgG1) at 2μg/ml (100 μl/well) can bind Recombinant Human PCSK9 V2 (D374Y, C-6His) (Cat#orb2992748) . The ED50 of Recombinant Human PCSK9 V2 (D374Y, C-6His) (Cat#orb2992748) is 30.94 ng/ml. (Regularly tested) . BLI: Loaded Anti-Human PCSK9 mAb (Human IgG1) on Pro-A Biosensor, can bind Recombinant Human PCSK9 V2 (D374Y, C-6His) (Cat#orb2992748) with an affinity constant of 2.77 nM as determined in BLI assay. (Regularly tested)
Form
Lyophilized
Molecular Weight
Predicted: 71.9 KDa. Observed: (17-21) & (60-70) KDa, reducing conditions
Storage Conditions
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Notes
For research use only.
Preservative
0.2 μm filtered solution of 20mM NaH2PO4, 150mM NaCl, 0.1M Arginine, 0.1M Glu, 0.01% Tween20, pH 7.4.

UniProtKB · Q8NBP7

Proprotein convertase subtilisin/kexin type 9

PCSK9_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8NBP7
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PCSK9
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.21.-
Processing
Precursor
Secondary accessions
A8T640, C0JYY9, Q5PSM5, Q5SZQ2
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisCholesterol metabolismLipid metabolismSteroid metabolismSterol metabolism

PTM

Autocatalytic cleavageDisulfide bondGlycoproteinPhosphoproteinSulfationZymogen

Ligand

Calcium

Cellular component

CytoplasmEndoplasmic reticulumEndosomeGolgi apparatusLysosomeSecreted

Disease

Disease variant

Molecular function

HydrolaseProteaseSerine protease

Domain

Signal

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