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Vindoline

CAT: 0804-HY-N0687-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0687-01Size:5 mg
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Description
Vindoline is an orally active vinca alkaloid. Vindoline can be extracted from the leaves of Catharanthus roseus. Vindoline has a weak inhibitory effect on the self-assembly of tubulin. Vindoline alleviates Apoptosis, inhibits p-p65 and p-ERK. Vindoline improves diabetes, bone loss, osteoarthritis, and kidney damage[1][2][3][4][5].
CAS Number
[2182-14-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Microtubule/Tubulin; NF-κB; PERK
Type
Natural Products
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Endocrinology; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/vindoline.html
Concentration
10mM
Purity
99.95
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
CC[C@@]1(C=CCN2CC3)[C@@]2([H])[C@@]3(C4=CC=C(OC)C=C4N5C)[C@]5([H])[C@](C(OC)=O)(O)[C@@H]1OC(C)=O
Molecular Formula
C25H32N2O6
Molecular Weight
456.53
Precautions
H302, H315, H319, H335
References & Citations
[1]Prakash V, et al. Mechanism of interaction of vinca alkaloids with tubulin: catharanthine and vindoline. Biochemistry. 1991 Jan 22;30 (3) :873-80.|[2]Yao XG, et al. Natural product vindoline stimulates insulin secretion and efficiently ameliorates glucose homeostasis in diabetic murine models. J Ethnopharmacol. 2013 Oct 28;150 (1) :285-97.|[3]Zhan Y, et al. Vindoline Inhibits RANKL-Induced Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss in Mice. Front Pharmacol. 2020 Jan 22;10:1587.|[4]Wang Z, et al. Vindoline mitigates cisplatin-mediated kidney damage by alleviating redox imbalance, apoptosis and inflammation through extracellular signal-regulated kinase pathway modulation. J Physiol Pharmacol. 2024 Dec;75 (6) .|[5]Zhu M, et al. Vindoline Attenuates Osteoarthritis Progression Through Suppressing the NF-κB and ERK Pathways in Both Chondrocytes and Subchondral Osteoclasts. Front Pharmacol. 2022 Jan 12;12:764598.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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