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β-Glucogallin

CAT: 0804-HY-133708-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-133708-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
β-Glucogallin is an orally active and selective aldose reductase (AKR1B1) inhibitor with an IC50 value of 58 μM when using Glyceraldehyde as AKR1B1 substrate. β-Glucogallin reduces ROS, PDGF, RAGE, and NF-κB. β-Glucogallin increases SOD. β-Glucogallin has antioxidant and hepatoprotective effects. β-Glucogallin can be used in retinal research[1][2][3][4][5].
CAS Number
13405-60-2
Product Name Alternative
1-O-Galloyl-β-D-glucose
UNSPSC
12352005
Hazard Statement
H302+H312+H332, H319, H335
Target
Aldose Reductase; NF-κB; PDGFR; Reactive Oxygen Species (ROS) ; SOD
Type
Natural Products
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/β-glucogallin.html
Purity
99.82
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 4.17 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@H](OC(C2=CC(O)=C(O)C(O)=C2)=O)O[C@H](CO)[C@@H](O)[C@@H]1O
Molecular Formula
C13H16O10
Molecular Weight
332.26
Precautions
H302+H312+H332, H319, H335
References & Citations
[1]Li L, et al. Design of an amide N-glycoside derivative of β-glucogallin: a stable, potent, and specific inhibitor of aldose reductase. J Med Chem. 2014 Jan 9;57 (1) :71-7.|[2]Ma Y, Liu F, Xu Y. Protective Effect of β-Glucogallin on Damaged Cataract Against Methylglyoxal Induced Oxidative Stress in Cultured Lens Epithelial Cells. Med Sci Monit. 2019 Dec 7;25:9310-9318. |[3]Puppala M, Ponder J, Suryanarayana P, Reddy GB, Petrash JM, LaBarbera DV. The isolation and characterization of β-glucogallin as a novel aldose reductase inhibitor from Emblica officinalis. PLoS One. 2012;7 (4) :e31399.|[4]Li L, Chang KC, Zhou Y, Shieh B, Ponder J, Abraham AD, Ali H, Snow A, Petrash JM, LaBarbera DV. Design of an amide N-glycoside derivative of β-glucogallin: a stable, potent, and specific inhibitor of aldose reductase. J Med Chem. 2014 Jan 9;57 (1) :71-7.|[5]Majeed M, et al. Amelioration of carbon tetrachloride induced hepatotoxicity by Β-glucogallin, a gallic acid derivative of emblica officinalis gaertn. (euphorbiaceae) . Science, 2015, 4 (7) : 696-701.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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