Ficonalkib

Chemical Information
Ficonalkib is an orally bioavailable, third-generation inhibitor of the receptor tyrosine kinase (RTK) anaplastic lymphoma kinase (ALK), with potential antineoplastic activity. Upon oral administration, ficonalkib binds to and inhibits ALK wild-type tyrosine kinase and numerous ALK mutations, including acquired resistance mutations. Inhibition of ALK leads to the disruption of ALK-mediated signaling and the inhibition of cell growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a variety of tumor cell types.
| CAS Number | 2233574-95-1 |
| PubChem CID | 135211735 |
| IUPAC Name | 2-N-[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyphenyl]-4-N-(2-propan-2-ylsulfonylphenyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-2,4-diamine |
| Molecular Formula | C29H39N7O3S |
| Molecular Weight | 565.7 |
| XLogP | 5.6 |
| Topological Polar Surface Area | 120 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 10 |
| Rotatable Bond Count | 9 |
| Heavy Atom Count | 40 |
| Formal Charge | 0 |
| Complexity | 908 |
| Property | Value |
|---|---|
| Molecular Weight | 565.7 |
| XLogP3 | 5.6 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 10 |
| Rotatable Bond Count | 9 |
| Exact Mass | 565.28350931 |
| Monoisotopic Mass | 565.28350931 |
| Topological Polar Surface Area | 120 Ų |
| Heavy Atom Count | 40 |
| Formal Charge | 0 |
| Complexity | 908 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Alternative Products
| Catalog | Name |
|---|---|
| MBS5815375 | Ficonalkib |
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