Lynestrenol

CAT: 0804-HY-109568-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-109568-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Lynestrenol is a pregnane X receptor (PXR) agonist with the EC50s of 41 and 0.23 μM for hPXR and zfPXR, respectively[1]. Lynestrenol, a synthetic progesteronelike agent possess immunostimulatory properties[2][3].

CAS Number

52-76-6

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Pregnane X Receptor (PXR)

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Endocrinology; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/lynestrenol.html

Purity

99.87

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@](CC[C@@]2(O)C#C)([H])[C@@]3([H])[C@]([C@]4([H])C(CC3)=CCCC4)([H])CC1

Molecular Formula

C20H28O

Molecular Weight

284.44

Precautions

H302, H315, H319, H335

References & Citations

[1]Nicolas Creusot, et al. A Comparative Study of Human and Zebrafish Pregnane X Receptor Activities of Pesticides and Steroids Using In Vitro Reporter Gene Assays. Front Endocrinol (Lausanne) . 2021 May 18;12:665521.|[2]J Wybran. Lynestrenol: a progesteronelike agent with immunostimulatory properties. Recent Results Cancer Res. 1980;75:180-4.|[3]Yasir Hasan Siddique, et al. In vivo induction of sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) by lynestrenol. Indian J Exp Biol. 2005 Mar;43 (3) :291-3.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

Phase 4

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454043-01	Lynestrenol
A17461-100	Lynestrenol 100mg
A17461-50	Lynestrenol 50mg
A17461-25	Lynestrenol 25mg
MBS5786110	Lynestrenol acetate

Lynestrenol

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