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7ACC2

CAT: 0804-HY-D0713-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-D0713-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
7ACC2 is a potent monocarboxylate transporter (MCT) inhibitor with an IC50 of 11 nM for inhibition of [14C]-lactate influx. 7ACC2 is also a potent inhibitor of mitochondrial pyruvate transport. 7ACC2 is an anticancer agent through inhibition of lactate flux[1][2].
CAS Number
1472624-85-3
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Mitochondrial Metabolism; Monocarboxylate Transporter
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/7ACC2.html
Purity
99.73
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CN(C1=CC=C(C=C(C(O)=O)C(O2)=O)C2=C1)CC3=CC=CC=C3
Molecular Formula
C18H15NO4
Molecular Weight
309.32
Precautions
H302, H312, H332
References & Citations
[1]Draoui N, et al. Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells. Bioorg Med Chem. 2013 Nov 15;21 (22) :7107-17.|[2]Cyril Corbet, et al. Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects. Nat Commun. 2018 Mar 23;9 (1) :1208.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Inhibitory Antibodies
Clinical Information
No Development Reported

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