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2-Bromohexadecanoic acid

CAT: 0804-HY-111770-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111770-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
2-Bromohexadecanoic acid (2-Bromopalmitate; 2-BP) is a palmitoylation inhibitor targeting DHHC (Asp-His-His-Cys) protein palmitoyltransferase. 2-Bromohexadecanoic acid inhibits palmitoylation of GSDME-C during pyroptosis and inhibits BAK/BAX-Caspase 3-GSDME pathway-mediated pyroptosis[1].
CAS Number
18263-25-7
Product Name Alternative
2-Bromopalmitic acid; 2-Bromopalmitate
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
Pyroptosis
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/2-bromohexadecanoic-acid.html
Concentration
10mM
Purity
99.95
Solubility
DMSO : ≥ 125 mg/mL
Smiles
CCCCCCCCCCCCCCC(Br)C(O)=O
Molecular Formula
C16H31BrO2
Molecular Weight
335.32
Precautions
H315, H319, H335
References & Citations
[1]Hu L, et al. Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate. Cell Death Dis. 2020 Apr 24;11 (4) :281.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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