MN551

CAT: 0804-HY-156395-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-156395-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

MN551 is a potent inhibitor of cysteine-directed electrophilic covalent that plays important roles in the biology of SOCS2 and its CRL5 complex, and as E3 ligase handles in proteolysis targeting chimera (PROTACs) to induce targeted protein degradation[1].

UNSPSC

12352005

Target

E1/E2/E3 Enzyme

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mn551.html

Purity

99.36

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC1=CC=C(CC(N[C@@H](CC2=CC=C(OP(O)(O)=O)C=C2)C(NCC3=CC=CC(NC(CCl)=O)=C3)=O)=O)C=C1

Molecular Formula

C26H26ClFN3O7P

Molecular Weight

577.93

References & Citations

[1]Sarath Ramachandran, et al. Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2. Nat Commun. 2023 Oct 10;14 (1) :6345.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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