Miglustat (hydrochloride)

Miglustat (hydrochloride)

• CAS Number: 210110-90-0
• UNSPSC Description: Miglustat (N-Butyldeoxynojirimycin) hydrochloride is an orally active and reversible ceramide glucosyltransferase inhibitor. Miglustat hydrochloride can be used for the research of type I gaucher disease[1][2].
• Target Antigen: Glucosylceramide Synthase (GCS)
• Type: Reference compound
• Related Pathways: Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Inflammation/Immunology; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/Miglustat-hydrochloride.html
• Solubility: DMSO : 65 mg/mL (ultrasonic)|H2O : ≥ 34 mg/mL
• Smiles: O[C@H]1[C@H](O)[C@@H](CO)N(CCCC)C[C@@H]1O.[H]Cl
• Molecular Weight: 255.74
• References & Citations: [1]Maria Cristina Dechecchi, et al. Anti-inflammatory effect of miglustat in bronchial epithelial cells. J Cyst Fibros. 2008 Nov;7(6):555-65. |[2]G D'Arcangelo, et al. Miglustat Reverts the Impairment of Synaptic Plasticity in a Mouse Model of NPC Disease. Neural Plast. 2016:2016:3830424. Cell. 2019 Dec 12;179(7):1483-1498.e22.|Cell Rep. 2022 Jul 5;40(1):111049.|Nat Commun. 2024 Aug 14;15(1):6970.|Preprints. 2023 Dec 20.
• Shipping Conditions: Blue Ice
• Clinical Information: Launched