(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone

(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone

• CAS Number: 878800-84-1
• UNSPSC Description: (3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3), a Palmitate, can be isolated from the root tissue of Salvia miltiorrhiza. (3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3) shows anti-cancer activity against human cancer cell lines with DC50s of 25.5 μg/mL (HeLa), 37.5 μg/mL (HepG2), 30.2 μg/mL (OVCAR-3), respectively[1].
• Target Antigen: Others
• Type: Natural Products
• Related Pathways: Others
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/3s-4as-10as-3-acetyloxy-2-3-4-4a-10-10a-hexahydro-6-hydroxy-1-1-4a-trimethyl-7-1-methylethyl-9-1h-phenanthrenone.html
• Solubility: 10 mM in DMSO
• Smiles: CC(C(C=C12)=C(O)C=C2[C@@](C)(C[C@@H](OC(C)=O)CC3(C)C)[C@H]3CC1=O)C
• Molecular Weight: 358.47
• References & Citations: [1]Don MJ, et al. Cytotoxic and aromatic constituents from Salvia miltiorrhiza. Phytochemistry. 2006 Mar;67(5):497-503.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported