(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone

• UNSPSC Description:

  (3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3), a Palmitate, can be isolated from the root tissue of Salvia miltiorrhiza. (3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3) shows anti-cancer activity against human cancer cell lines with DC50s of 25.5 μg/mL (HeLa), 37.5 μg/mL (HepG2), 30.2 μg/mL (OVCAR-3), respectively[1].

• Target Antigen:

  Others

• Type:

  Natural Products

• Related Pathways:

  Others

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/3s-4as-10as-3-acetyloxy-2-3-4-4a-10-10a-hexahydro-6-hydroxy-1-1-4a-trimethyl-7-1-methylethyl-9-1h-phenanthrenone.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C(C=C12)=C(O)C=C2[C@@](C)(C[C@@H](OC(C)=O)CC3(C)C)[C@H]3CC1=O)C

• Molecular Weight:

  358.47

• References & Citations:

  [1]Don MJ, et al. Cytotoxic and aromatic constituents from Salvia miltiorrhiza. Phytochemistry. 2006 Mar;67(5):497-503.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  878800-84-1