Recombinant Human I-TAC/CXCL11 protein

Recombinant Human I-TAC/CXCL11 protein

• Background: CXCL11 also known as I-TAC is belonging to the CXC chemokine family and shares 36 % and 37 % amino acid sequence homology with IP-10 and MIG, respectively. It is highly expressed in peripheral blood leukocytes, pancreas and liver. Expression of CXCL11 is strongly induced by IFN-γ and IFN-β, and weakly induced by IFN-α. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3, which with a higher affinity than do the other chemokines for this receptor, CXCL9 and CXCL10. Similar to CXCL10, CXCL11 has been shown to be a chemoattractant for IL-2-activated T-lymphocytes, but not for isolated T-cells, neutrophils or monocytes.
• CAS Number: 9000-83-3
• Reconstitution: Lyophilized from a .2 μm filtered solution of 2mM Tris-HCl, 15mM NaCl, 1mM EDTA, pH 8..
• Molecular Weight: Approximately 8.3 kDa, a single non-glycosylated polypeptide chain containing 73 amino acids.