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Recombinant Human MANF protein

CAT: 0772-CD01339Size: 5 µgDry Ice: NoHazardous: No
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CAT#:0772-CD01339Size:5 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. MANF and its structural homolog CDNF, each contain an N-terminal saposin-like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. MANF and CDNF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease. Mature human MANF is 99 %, 98 % and 96 % a.a. identical to mature rat, mouse and bovine MANF respectively.
CAS Number
9000-83-3
Molecular Weight
Approximately 18.2 kDa, a single non-glycosylated polypeptide chain containing158 amino acids.

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