Products for Research Use Only
RegisterLogin

Recombinant Human MIC-A protein

CAT: 0772-CD01294Size: 10 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0772-CD01294Size:10 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
MIC-A (MHC class I chain-related gene A) is a single-pass type I member protein. It is expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Additionally, MIC-A can be induced by bacterial and viral infections. It shares 85 % amino acid identity with MIC-B and they are distantly related to the MHC class I proteins. Because they possess three extracellular Ig-like domains, but unlike classical MHC class I molecules. They do not form a heterodimer with beta2 microglobulin, but bind as a monomer to a KLRK1/NKG2D that is an activating receptor expressed on NK cells, NKT cells, γδ T cells, and CD8+ αβ T cells. Recognition of MICA by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. MIC-A recognition plays an important role in tumor surveillance, viral infections, and autoimmune diseases.
CAS Number
9000-83-3
Molecular Weight
Approximately 32.8 kDa, a single non-glycosylated polypeptide chain containing 285 amino acids.

Related Products

CatalogName
E7840Hu-01Human Colon cancer-associated protein Mic1, Mic-1 ELISA KIT
BT-AP05409-01Mic-1 Polyclonal Antibody
BT-AP03612-01MIC-A Rabbit Polyclonal Antibody
CD01295-01Recombinant Human MIC4 protein (C-Fc)
CD00977-01Recombinant Human S100A16 protein
CD01175-01Recombinant Human OSM protein
CD01630-01Recombinant Human HTN3 protein
CD00864-01Recombinant Human STX8 protein
CD02179-01Recombinant Human CAT protein
CD01787-01Recombinant Human FIBP protein

Alternative Products

CatalogName
E900172PRecombinant Human MIC-A Protein
HEOPP-1305Recombinant Human MIC-A
RP02440Biotinylated Recombinant Human MIC-A Protein
RP02441Recombinant Human MIC-B Protein
MBS480573-01MIC-1, Recombinant Human Protein
P7149-500μgRecombinant Human MIC-B
HEOPP-136Recombinant Human MIC-A, His
RP02442Biotinylated Recombinant Human MIC-B Protein
P7145-10μgRecombinant Human MIC-A, His-tag
40-645GDF-15/MIC-1 Recombinant Protein

Popular Products