Recombinant Human MIP-1 Alpha/CCL3 protein

Recombinant Human MIP-1 Alpha/CCL3 protein

• Background: CCL3, also known as macrophage inflammatory protein-1α (MIP-1α), is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes. Studies showed CCL3 can bind to CCR1, CCR4 and CCR5. MIP-1α can induce a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). Recombinant human MIP-1α is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines and it shares approximately 73 %, 74 % and 92 % amino acid sequence homology with the Mouse, rat and rhesus macaque protein.
• CAS Number: 9000-83-3
• Reconstitution: Supplied as a .2 μm filtered solution of 2mM TrisHCl, 15mM NaCl, 1% Glycerol, pH 7.5.
• Molecular Weight: Approximately 7.8 kDa protein containing 7 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.