Recombinant Human PTHrP protein

Recombinant Human PTHrP protein

• Background: Parathyroid Hormone-like related Protein (PTHrP) is a member of the Parathyroid hormone family that is expressed in the mammary gland. It is known as a potent inhibitor of chondrocyte maturation. PTHrP is expressed by periarticular perichondrial cells and exerts its biological activity on PP-R expressing cells. During endochondral bone development PTHrP plays a major role in suppressing the onset of hypertrophic differentiation. PTHrP plays a central role in regulating the extracellular concentrations of calcium and phosphorous and it is responsible for most cases of humoral hypercalcemia of malignancy.
• CAS Number: 9000-83-3
• Reconstitution: Supplied as a .2 μm filtered solution of PBS, pH 7.4.
• Molecular Weight: Approximately 9.9 kDa, a single non-glycosylated polypeptide chain containing 86 amino acids.