Recombinant Human Rb protein

Recombinant Human Rb protein

• Background: Rb encoded by the RB1 gene in humans, is expressed by retina and belongs to the etinoblastoma-associated protein family. The hole protein consists of 928 a.a. and the rHuRb fragment occupies sequence of 792-929 a.a.. Rb is a key regulator of entry into cell division that acts as a tumor suppressor. It has many functions, for example, promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C, and acts as a transcription repressor of E2F1 target genes and so on. The rHuRb is the region that rich of modified residue like phosphothreonine and N6-acetyllysine.
• CAS Number: 9000-83-3
• Reconstitution: Lyophilized from a .2 μm filtered solution of 2mM PB, 15mM NaCl, pH 7.2.
• Molecular Weight: Approximately 16.5 kDa, a single non-glycosylated polypeptide chain containing 146 amino acids.