Recombinant Mouse Bcl-xL protein

Recombinant Mouse Bcl-xL protein

• Background: Bcl-xL is a transmembrane protein located in the mitochondrial membranes of cells that are long-lived and postmitotic, such as adult brain cells. It plays a role in the signal transduction pathway of the FAS-Ligand. Bcl-xL is an anti-apoptotic protein which is a member of the Bcl-2 family which are able to form heterodimers, and this is an significant event in the regulation of apoptosis. It is involved in the survival of cancer cells. Bcl-xL is the leading monitor of apoptosis/active cell suicide. It has cell death repressor activity and therefore acts as a survival protein. The Mouse Bcl-xL shares 97 % and 99 % a.a. sequence identity with human and rat Bcl-xL, respectively.
• CAS Number: 9000-83-3
• Reconstitution: Lyophilized from a .2 μm filtered solution of 2mM Tris, 15mM NaCl, pH 8..
• Molecular Weight: Approximately 23.7 kDa, a single non-glycosylated polypeptide chain containing 211 amino acids.