Recombinant Mouse C10/CCL6 protein

Recombinant Mouse C10/CCL6 protein

• Background: Chemokine (C-C motif) ligand 6 (CCL6), encoded by the gene CCL6, is a small cytokine belonging to the CC chemokine family that has only been identified in rodents. Mouse CCL6 is expressed in myelopoietic bone marrow cultures when stimulated with GM-CSF, M-CSF, IL-3 or IL-4 and has also been detected in an IL-2-dependent T cell line, where the expression is inhibited following T cell stimulation. It signals primarily through the CCR1 receptor. CCL6 is chemotactic for B cells, CD4+ T cells, monocytes and NK cells and also exhibits powerful suppressive activity on colony formation by different lineages of hematopoietic progenitors. The C10 contains the four highly conserved cysteine residues present in CC chemokines.
• CAS Number: 9000-83-3
• Reconstitution: Supplied as a .2 μm filtered solution of 2mM Tris, 15mM NaCl, pH 8..
• Molecular Weight: Approximately 1.7 kDa, a single non-glycosylated polypeptide chain containing 95 amino acids.