Recombinant Mouse MDC/CCL22 protein

• Background:

  CCL22 is a protein that in mouse is encoded by the CCL22 gene, which locates on the Chr. 8. It is highly expressed in macrophage, monocyte-derived dendritic cell and thymus, additionally, also detected in the tissues of thymus, lymph node and appendix. CCL22 can bind to CCR4, and is a chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells, but not for neutrophils, eosinophils, and resting T-lymphocytes. After secreted from monocyte-derived dendritic cells, the protein can be proteolytic cleaved into three forms: MDC (3-69), MDC (5-69), MDC (7-69).

• CAS Number:

  9000-83-3

• Reconstitution:

  Lyophilized from a .2 μm filtered concentrated solution in 2 × PBS, pH7.4.

• Molecular Weight:

  Approximately 7.8 kDa, a single, non-glycosylated polypeptide chain containing 68 amino acids.