L-Leucyl-L-Leucine methyl ester (hydrochloride)

L-Leucyl-L-Leucine methyl ester (hydrochloride)

• Alternative Name: LLOMe (hydrochloride); Leu-Leu methyl ester (hydrochloride); H-Leu-Leu-OMe (hydrochloride)
• CAS Number: 6491-83-4
• UNSPSC Description: L-Leucyl-L-Leucine methyl ester (LLOMe) hydrochloride, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrochloride also can induce endolysosomal pathway stress[1][2][3].
• Target Antigen: Endogenous Metabolite
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/l-leucyl-l-leucine-methyl-ester-hydrochloride.html
• Purity: 99.50
• Solubility: DMSO : 250 mg/mL (ultrasonic)
• Smiles: CC(C)C[C@@H](C(OC)=O)NC([C@H](CC(C)C)N)=O.[H]Cl
• Molecular Weight: 294.82
• References & Citations: [1]Thiele DL, et, al. The immunosuppressive activity of L-leucyl-L-leucine methyl ester: selective ablation of cytotoxic lymphocytes and monocytes. J Immunol. 1986 Feb 1;136(3):1038-48.|[2]Thiele DL, et, al. Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells. Proc Natl Acad Sci U S A. 1990 Jan;87(1):83-7.|[3]Kalogeropulou AF, et, al. Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity. Biochem J. 2020 Nov 27;477(22):4397-4423.Autophagy. 2024 Jul 30.|bioRxiv. 2024 Mar 13.|PLoS Pathog. 2024 Feb 14;20(2):e1011981.|Traffic. 2022 May;23(5):238-269.|bioRxiv. 2024 July 07.|Int Immunol. 2021 Jul 23;dxab044.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported