Sodium 4-phenylbutyrate (Standard)

Sodium 4-phenylbutyrate (Standard)

• CAS Number: 1716-12-7
• UNSPSC Description: Sodium 4-phenylbutyrate (Standard) is the analytical standard of Sodium 4-phenylbutyrate. This product is intended for research and analytical applications. Sodium 4-phenylbutyrate (4-PBA sodium) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research[1].
• Target Antigen: Apoptosis; Autophagy; HDAC
• Type: Reference Standards
• Related Pathways: Apoptosis;Autophagy;Cell Cycle/DNA Damage;Epigenetics
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/sodium-4-phenylbutyrate-standard.html
• Smiles: O=C(O[Na])CCCC1=CC=CC=C1
• Molecular Weight: 186.18
• References & Citations: [1]Chang TH, et al. Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung. Clin Cancer Res. 2002 Apr;8(4):1206-12.|[2]Frouco G, et, al. Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14. Virus Res. 2017 Oct 15;242:24-29.|[3]Park HJ, et al. 4-Phenylbutyric acid protects against lipopolysaccharide-induced bone loss by modulating autophagy in osteoclasts. Biochem Pharmacol. 2018 May;151:9-17.
• Shipping Conditions: Room temperature