L-690330

• Description :

  L-690330 is a competitive inhibitor of inositol monophosphatase (IMPase) with Kis of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively. L-690330 exhibits 10-fold more sensitive than mouse and rat IMPase[1].

• CAS Number :

  [142523-38-4]

• UNSPSC :

  12352005

• Target :

  Phosphatase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/l-690330.html

• Purity :

  99.52

• Solubility :

  H2O : 66.67 mg/mL (ultrasonic)

• Smiles :

  OC1=CC=C(OC(P(O)(O)=O)(P(O)(O)=O)C)C=C1

• Molecular Formula :

  C8H12O8P2

• Molecular Weight :

  298.12

• References & Citations :

  [1]Atack JR, et al. In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330. J Neurochem. 1993 Feb;60 (2) :652-8.|[2]Cárdenas C, et al. Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.Cell. 2010 Jul 23;142 (2) :270-83.|[3]Shtein L, et al. The inositol monophosphatase inhibitor L-690,330 affects pilocarpine-behavior and the forced swim test.Psychopharmacology (Berl) . 2013 Jun;227 (3) :503-8.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported