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Lapaquistat acetate

CAT: 0804-HY-16274-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16274-01Size:1 mg
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Description
Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor, blocking the conversion of farnesyl diphosphate (FPP) to squalene in the cholesterol biosynthesis pathway[1]. Lapaquistat acetate is effective at lowering low-density lipoprotein cholesterol, but it might cause liver damage. Lapaquistat acetate is used for hypercholesterolemia and mevalonate kinase deficiency (MKD) research[2].
CAS Number
189060-13-7
Product Name Alternative
TAK-475
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Farnesyl Transferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/lapaquistat-acetate.html
Purity
99.10
Solubility
DMSO : 2 mg/mL (ultrasonic)
Smiles
O=C(O)CC1CCN(C(C[C@@H]2C(N(CC(C)(C)COC(C)=O)C3=CC=C(Cl)C=C3[C@@H](C4=CC=CC(OC)=C4OC)O2)=O)=O)CC1
Molecular Formula
C33H41ClN2O9
Molecular Weight
645.14
Precautions
H302, H315, H319, H335
References & Citations
[1]Stein EA, et al. Lapaquistat acetate: development of a squalene synthase inhibitor for the treatment of hypercholesterolemia. Circulation. 2011 May 10;123 (18) :1974-85.|[2]Marcuzzi A, et al. Repositioning of Tak-475 In Mevalonate Kinase Disease: Translating Theory Into Practice. Curr Med Chem. 2018;25 (24) :2783-2796.|[3]M Shiomi, et al. Lapaquistat acetate, a squalene synthase inhibitor, changes macrophage/lipid-rich coronary plaques of hypercholesterolaemic rabbits into fibrous lesions. Br J Pharmacol. 2008 Jul;154 (5) :949-57.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
PHA06013-01Lapaquistat acetate
A20851-25Lapaquistat acetate 25mg
A20851-1Lapaquistat acetate 1mg
A20851-10Lapaquistat acetate 10mg
A20851-5Lapaquistat acetate 5mg
A20851-100Lapaquistat acetate 100mg
A20851-50Lapaquistat acetate 50mg
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