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Aloxistatin

CAT: 0804-HY-100229-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100229-01Size:1 mg
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Description
Aloxistatin (E64d) is a cell-permeable and irreversible broad-spectrum cysteine protease inhibitor. Aloxistatin (E64d) exhibits entry-blocking effect for MERS-CoV.
CAS Number
88321-09-9
Product Name Alternative
E64d; E64c ethyl ester
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cathepsin; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Aloxistatin.html
Purity
99.94
Solubility
DMSO : 116.67 mg/mL (ultrasonic) |Ethanol : ≥ 33.33 mg/mL
Smiles
O=C([C@H]1O[C@@H]1C(N[C@H](C(NCCC(C)C)=O)CC(C)C)=O)OCC
Molecular Formula
C17H30N2O5
Molecular Weight
342.43
Precautions
H302, H315, H319, H335
References & Citations
[1]Doh-Ura K, et al. Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation. J Virol. 2000 May;74 (10) :4894-7.|[2]Konjar S, et al. Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L. Immunology. 2010 Oct;131 (2) :257-67.|[3]Mullins SR, et al. Three-dimensional cultures modeling premalignant progression of human breast epithelial cells: role of cysteine cathepsins. Biol Chem. 2012 Dec;393 (12) :1405-16.|[4]Hook G, et al. The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity. J Alzheimers Dis. 2011;26 (2) :387-408.|[5]Cheng XW, et al. Superoxide-dependent cathepsin activation is associated with hypertensive myocardial remodeling and represents a target for angiotensin II type 1 receptor blocker treatment. Am J Pathol. 2008 Aug;173 (2) :358-69.|[6]Ji Yeun Kim, et al. Safe, High-Throughput Screening of Natural Compounds of MERS-CoV Entry Inhibitors Using a Pseudovirus Expressing MERS-CoV Spike Protein. Int J Antimicrob Agents. 2018 Nov;52 (5) :730-732.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3

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