2-Phenylacetamide

• Description:

  2-Phenylacetamide is a estrogen-like compound that can be isolated from Lepidium apetalum seeds. 2-Phenylacetamide inhibits p38 MAPK signaling pathway, exhibits anti-inflammatory, antioxidant, anti-hypertensive, and anti-fibrosis effects. 2-Phenylacetamide is orally active[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H301, H319

• Target:

  Endogenous Metabolite; p38 MAPK; Reactive Oxygen Species (ROS)

• Type:

  Natural Products

• Related Pathways:

  Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cancer; Metabolic Disease; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/2-phenylacetamide.html

• Purity:

  99.92

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(N)CC1=CC=CC=C1

• Molecular Formula:

  C8H9NO

• Molecular Weight:

  135.17

• Precautions:

  H301, H319

• References & Citations:

  [1]Zeng M, et al., 2-Phenylacetamide Isolated from the Seeds of Lepidium apetalum and Its Estrogen-Like Effects In Vitro and In Vivo. Molecules. 2018 Sep 7;23 (9) :2293.|[2]Yuan PP, et al., 2-phenylacetamide Separated from the seed of Lepidium apetalum Willd. inhibited renal fibrosis via MAPK pathway mediated RAAS and oxidative stress in SHR Rats. BMC Complement Med Ther. 2023 Jun 23;23 (1) :207.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  Human Endogenous Metabolite

• CAS Number:

  [103-81-1]