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UNC2400

CAT: 0804-HY-12845-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12845-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UNC2400 is a close analog of UNC1999 with >1,000-fold lower potency than UNC1999 as a negative control for cell-based studies[1][2].
CAS Number
[1433200-49-7]
UNSPSC
12352005
Target
Autophagy; Histone Methyltransferase
Type
Reference compound
Related Pathways
Autophagy; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/unc2400.html
Purity
99.92
Solubility
DMSO : 65 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC(C2=CC=C(N3CCN(C(C)C)CC3)N=C2)=CC4=C1C=NN4C(C)C)N(CC5=C(CCC)C=C(C)N(C)C5=O)C
Molecular Formula
C35H47N7O2
Molecular Weight
597.79
References & Citations
[1]Kyle D Konze, et al. An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. ACS Chem Biol. 2013;8 (6) :1324-34.|[2]Bowen Xu, et al. Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia. Blood. 2015 Jan 8;125 (2) :346-57.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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