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Gimatecan

CAT: 0804-HY-B0063-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0063-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Gimatecan (ST1481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity[1].
CAS Number
292618-32-7
Product Name Alternative
ST1481
UNSPSC
12352005
Hazard Statement
H301
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gimatecan.html
Purity
99.28
Solubility
DMSO : 6.67 mg/mL (ultrasonic; warming; adjust pH to 5 with 1 M HCL; heat to 60°C)
Smiles
CC(C)(C)O/N=C/C1=C2C(C(N3C2)=CC([C@@]4(O)CC)=C(COC4=O)C3=O)=NC5=CC=CC=C15
Molecular Formula
C25H25N3O5
Molecular Weight
447.48
Precautions
H301
References & Citations
[1]Paola Ulivi, et al. Cellular Basis of Antiproliferative and Antitumor Activity of the Novel Camptothecin Derivative, Gimatecan, in Bladder Carcinoma Models. Neoplasia. 2005 Feb;7 (2) :152-61.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Topo I

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