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Tiazofurin

CAT: 0804-HY-114570-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114570-01Size:1 mg
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Description
Tiazofurin (NSC 286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH) . Tiazofurin enhances the autosecretion of IL-6 in K562 cells. Tiazofurin also has anti-orthopoxvirus and anti-variola activities. Tiazofurin can be used for the study of leukemia and lung cancer[1][2][3][4].
CAS Number
60084-10-8
Product Name Alternative
NSC 286193; Riboxamide
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Nucleoside Antimetabolite/Analog; Orthopoxvirus
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tiazofurin.html
Purity
99.84
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(N)C1=CSC([C@@H]2O[C@@H]([C@H]([C@H]2O)O)CO)=N1
Molecular Formula
C9H12N2O5S
Molecular Weight
260.27
Precautions
H302, H315, H319, H335
References & Citations
[1]Tricot G, Jayaram HN, Weber G, Hoffman R. Tiazofurin: biological effects and clinical uses. Int J Cell Cloning. 1990;8 (3) :161-170. |[2]Robert O Baker, et al. Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections. Antiviral Res. 2003 Jan;57 (1-2) :13-23. |[3]Talley CJ, et al. Tiazofurin-induced autosecretion of IL-6 and hemoglobin production in K562 human leukemia cells. Am J Hematol. 1997 Apr;54 (4) :301-5. |[4]Ahluwalia GS, et al. Studies on the mechanism of action of 2-beta-D-ribofuranosylthiazole-4-carboxamide--V. Factors governing the response of murine tumors to tiazofurin. Biochem Pharmacol. 1984 Apr 15;33 (8) :1195-203.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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