CCT245737 (SRA737)

CAT: 0244-S8253-1gSize: 1 gDry Ice: NoHazardous: No

1 / 1

CAT#:0244-S8253-1gSize:1 g

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

CAS Number

1489389-18-5

Chemical Information

Sra-737

Chk1 Inhibitor SRA737 is an orally bioavailable inhibitor of checkpoint kinase 1 (chk1), with potential antineoplastic and chemosensitization activities. Upon oral administration, chk1 inhibitor SRA737 selectively binds to chk1, thereby preventing chk1 activity and abrogating the repair of damaged DNA. This may lead to an accumulation of damaged DNA, inhibition of cell cycle arrest, and induction of apoptosis. SRA737 may potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapeutic agents. Chk1, an adenosine triphosphate (ATP)-dependent serine/threonine kinase overexpressed in a variety of cancer cell types, mediates cell cycle checkpoint control and is essential for DNA repair; it plays a key role in resistance to chemotherapeutic agents by repairing DNA damage.

CAS Number	1489389-18-5
PubChem CID	72165232
IUPAC Name	5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(trifluoromethyl)-2-pyridinyl]amino]pyrazine-2-carbonitrile
Molecular Formula	C16H16F3N7O
Molecular Weight	379.34
XLogP	1.1
Topological Polar Surface Area	108
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	5
Heavy Atom Count	27
Formal Charge	0
Complexity	526

SMILES

C1CO[C@H](CN1)CNC2=CC(=NC=C2C(F)(F)F)NC3=NC=C(N=C3)C#N

InChI

InChI=1S/C16H16F3N7O/c17-16(18,19)12-8-25-14(26-15-9-22-10(4-20)5-24-15)3-13(12)23-7-11-6-21-1-2-27-11/h3,5,8-9,11,21H,1-2,6-7H2,(H2,23,24,25,26)/t11-/m1/s1

InChIKey

YBYYWUUUGCNAHQ-LLVKDONJSA-N

Chemical Structure

2D Structure

CAS: 1489389-18-5

CID: 72165232

Formula: C16H16F3N7O

MW: 379.34

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	379.34
XLogP3	1.1
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	5
Exact Mass	379.13684265
Monoisotopic Mass	379.13684265
Topological Polar Surface Area	108 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	526
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
S8253-5mg	CCT245737 (SRA737)
BUP12330-01	CCT245737
A17239-50	CCT245737 50mg
A17239-10	CCT245737 10mg
A17239-25	CCT245737 25mg
T70553-01	CCT245737 (S)
A17239-100	CCT245737 100mg
A17239-5	CCT245737 5mg
A17239-2	CCT245737 2mg
HY-18958A	(S) -CCT245737

CCT245737 (SRA737)

Chemical Information

Alternative Products

Popular Products