Recombinant Integrin beta 5 Monoclonal Antibody

Recombinant Integrin beta 5 Monoclonal Antibody

• Background: Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors.
• Synonyms: FLJ26658,Integrin beta-5,Integrin subunit beta 5,integrin,beta 5,ITB5,Itgb5,Testis secretory sperm-binding protein Li 217p
• Gene ID: 3693
• Swiss Prot: P18084
• Host: Rabbit
• Reactivity: Human,Rat,Hamster
• Immunogen: Recombinant protein of human Integrin beta 5
• Clonality: Monoclonal
• Isotype: IgG
• Conjugation: Unconjugated
• Applications: WB
• Purification: Affinity purification
• Concentration: 300 μg/mL
• Dilution: WB 1:500-1:1000
• Buffer: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
• Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
• Calculated Molecular Weight: 54kDa
• Observed Molecular Weight: 54kDa