Recombinant Semaphorin 4D Monoclonal Antibody

Recombinant Semaphorin 4D Monoclonal Antibody

• Background: Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.
• Synonyms: A8,BB 18,BB18,CD 100,CD100,CD100 antigen,Coll 4,COLL4,Collapsin 4,Collapsin4,GR3,Leukocyte activation antigen CD100,M sema G,MSEMA,SEM4D,Sema 4d,Sema domain immunoglobulin domain Ig transmembrane domain TM and short cytoplasmic domain semaphorin 4D,Sema H,SEMA J,Sema4d,Semacl 2,Semacl2,SemaH,SEMAJ,Semaphorin 4D,Semaphorin C like 2,Semaphorin H,Semaphorin J,Semaphorin-4D,Semaphorin4D,SemaphorinJ,Semcl 2,Semcl2
• Gene ID: 10507
• Swiss Prot: Q92854
• Host: Rabbit
• Reactivity: Human
• Immunogen: A synthetic peptide of human Semaphorin 4D
• Clonality: Monoclonal
• Isotype: IgG
• Conjugation: Unconjugated
• Applications: WB
• Purification: Affinity purification
• Concentration: 300 μg/mL
• Dilution: WB 1:1000-1:5000
• Buffer: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
• Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
• Calculated Molecular Weight: 52kDa
• Observed Molecular Weight: 52kDa