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CD146/MCAM Polyclonal Antibody

CAT: 0866-RD90756A-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0866-RD90756A-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD146, also known as melanoma cell adhesion molecule (MCAM) or MUC18, originally identified as a biomarker of melanoma progression, is a transmembrane glycoprotein of 113-130 kDa, belonging to the immunoglobulin (Ig) superfamily. Structurally, it consists of five Ig domains, a transmembrane domain, and a cytoplasmic region. In normal adult tissue, CD146 is primarily expressed by vascular endothelium and smooth muscle. CD146 is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis, and has been used as marker of circulating endothelium cells (CECs) . In addition to the membrane-anchored form of CD146, a soluble form of CD146 (sCD146,105 kDa) has also been found in human plasma and in the supernatant of cultured human endothelial cells. This antibody detects a band at approximately 120 kDa that corresponds to the molecular weight of glycosylated CD146. Treatment of lysates of HepG2 cells and L02 cells with PNGase F, which removes oligosaccharides from N-linked glycoproteins, led to a down-shift of the detected band.
Description
This is a CD146/MCAM Polyclonal antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
CD146, MCAM, MUC18
Swiss Prot
P43121
Reactivity
Human
Immunogen
Recombinant Human CD146/MCAM protein expressed by? E.coli
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal antibody
Applications
WB
Purification Method
Antigen affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:1000
Buffer
PBS with 0.02% sodium azide,50% glycerol pH 7.4
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
44kDa
Observed Molecular Weight
43kDa
Host or Source
Rabbit
Isotype
IgG

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