ADAMTS4 Polyclonal Antibody

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

This is a ADAMTS4 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

ADAMTS4, ADAMTS-2, ADAMTS-4, ADMP-1

9507

O75173

Human, Mouse, Rat

Recombinant fusion protein of human ADAMTS4

Unconjugated

Polyclonal Antibody

IF

Affinity purification

Antibody

1mg/mL

IF 1:50-1:200

PBS with 0.05% proclin300,50% glycerol, pH7.3.

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

23kDa/25kDa

33KDa

Rabbit