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VHL Polyclonal Antibody

CAT: 0866-RD90067A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD90067A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Description
This is a VHL Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
VHL, HRCA1, RCA1, VHL1, pVHL, PVHL
Gene ID
7428
Swiss Prot
P40337
Reactivity
Human, Mouse
Immunogen
A synthetic peptide of human VHL
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.02% sodium azide,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
114kDa/131kDa
Observed Molecular Weight
170kDa
Host or Source
Rabbit
Isotype
IgG

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