TAB2 Polyclonal Antibody

CAT: 0866-RD90029A-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0866-RD90029A-01Size:60 μL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2) . Alternative splicing results in multiple transcript variants.
Description
This is a TAB2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
TAB2, CHTD2, MAP3K7IP2, TAB-2
Gene ID
23118
Swiss Prot
Q9NYJ8
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human TAB2
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.01% thiomersal,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
119kDa/133kDa
Observed Molecular Weight
150kDa
Host or Source
Rabbit
Isotype
IgG

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