BRCC3 Polyclonal Antibody

• Background:

  This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.

• Description:

  This is a BRCC3 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  BRCC3, BRCC36, C6.1A, CXorf53

• Gene ID:

  79184

• Swiss Prot:

  P46736

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein of human BRCC3

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1mg/mL

• Dilution:

  WB 1:500-1:2000

• Buffer:

  PBS with 0.02% sodium azide,50% glycerol, pH7.3.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  68kDa

• Observed Molecular Weight:

  80kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG