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BARD1 Polyclonal Antibody

CAT: 0866-RD88679A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD88679A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Description
This is a BARD1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
BARD1
Gene ID
12021
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein of mouse BARD1
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.02% sodium azide,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
41 kDa
Observed Molecular Weight
45kDa
Host or Source
Rabbit
Isotype
IgG

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