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Α-Actinin-4 Polyclonal Antibody

CAT: 0866-RD88543A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD88543A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.
Description
This is a α-Actinin-4 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
ACTN4, ACTININ-4, FSGS, FSGS1
Gene ID
81
Swiss Prot
O43707
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human α-Actinin-4
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.01% thiomersal,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
28kDa
Observed Molecular Weight
28kDa
Host or Source
Rabbit
Isotype
IgG

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