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INSIG1 Polyclonal Antibody

CAT: 0866-RD88531A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD88531A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants.
Description
This is a INSIG1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
INSIG1, CL6
Gene ID
3638
Swiss Prot
O15503
Reactivity
Human, Rat
Immunogen
A synthetic peptide of human INSIG1
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.01% thiomersal,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
13kDa
Observed Molecular Weight
13kDa
Host or Source
Rabbit
Isotype
IgG

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