PAPD5 Polyclonal Antibody

• Background :

  Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly (A tail creating a heterogeneous 3' poly (A tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation. Also functions as a catalytic subunit of a TRAMP-like complex which has a poly (A RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo (A tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro. Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1. Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion. Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation. Mediates 3' adenylation of H/ACA box snoRNAs (small nucleolar RNAs followed by its 3'-to-5' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation.

• Description :

  This is a PAPD5 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms :

  PAPD5, TRF4-2

• Gene ID :

  64282

• Swiss Prot :

  Q8NDF8

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant fusion protein of human PAPD5

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Polyclonal Antibody

• Applications :

  WB

• Purification Method :

  Affinity purification

• Assay Type :

  Antibody

• Concentration :

  1mg/mL

• Dilution :

  WB 1:500-1:2000

• Buffer :

  PBS with 0.01% thiomersal,50% glycerol, pH7.3.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  30kDa

• Observed Molecular Weight :

  30kDa

• Host or Source :

  Rabbit

• Isotype :

  IgG